Current Issue : July-September Volume : 2016 Issue Number : 3 Articles : 6 Articles
The aim of the study was to prepare and characterize solid dispersion of piroxicam, a non steroidal anti inflammatory drug having low solubility. The dissolution rate of the drug enhance by using Gellucire 50/13 polymer. The solid dispersion was prepared by hot melting method at 1:1 to 1:5 drug to polymer ratios. The 1:3 ratio shows solubility increments 12.96 folds. After solubility increments batch of pellet were prepared by utilising extruder and spheronizer. The prepared solid dispersions were characterized by differential scanning calorimetry (DSC), which indicated that there were no signs of interaction of the drug with the carriers used in the case of solid dispersions containing higher polymeric contents. At start by utilising super disintegrants the rate of dissolution get increase. The motic digital microscopy images of pellets showed that the pellets have spherical shape and their size depends on the carrier used. This research concludes that the solubility of piroxicam expanded by solid dispersion method and pellets are filled into capsule form for immediate release dosage form....
Electrospinning, an electrostatic fiber fabrication technique has displayed more intrigue and consideration in recent years because of its adaptability and potential for applications in different fields. The development of nanotechnology, scientists are more concentrating on properties of nanoscale materials. The prominent applications incorporate into tissue building, biosensors, filtration, wound dressings, drug conveyance and catalyst immobilization. The nanoscale structure is created by the utilization of strong electric field on polymer solution or melt. Various advantages like high surface area to volume ratio, tunable porosity and the ability to manipulate nanofiber composition in order to get desired properties and function. With these in points of view, we intend to exhibit in this survey, an outline of the electrospinning method with its promising favorable circumstances and potential applications. This paper talked about the electrospinning, spinnable polymers, parameters (solution and processing), which fundamentally influence the fiber morphology, solvent properties and melt electrospinning (other option to solution electrospinning). At last, focused on various application of electrospun fiber in different field....
The aim of present study was to develop N-carboxymethyl chitosan (MCC) coated Indinavir (INV)-loaded SLNs. IDV is HIV protease inhibitor with a short half-life, extensive first-pass metabolism and variable pH-dependent oral absorption. To overcome these drawbacks SLN was prepared for intestinal lymphatic drug transport. Screening of lipid was done on the basis of solubility of INV in different lipids. Compritol 888ATO was selected. Screening of surfactant was done by preparing INV-SLNs by high speed homogenization (HSH) followed by ultra sonication method and evaluated for particle size, zeta potential and PDI. Poloxamer 188 was selected. Optimization of formulation was done by 32 full factorial design. Independent variables were selected as conc. of surfactant and drug:lipid ratio while dependent variable as a particle size, zeta potential and %entrapment efficiency. Optimized formulation showed particle size 166.2 nm and zeta potential -15.9 and highest EE 83.69%. The Optimized formulation was converted into positively charged SLNs by using stearylamine as charge modifier in lipid phase. Effect of different conc. of stearlyamine was also done and then optimised formulation was used for coating with MCC polymer (1%) by overnight stirring. MCC coated SLNs was confirmed by change in zeta-potential and particle size. Particle size after coating was found to be 249.1 and zeta potential -9.37. Morphological study of optimized formulation was confirmed by SEM analysis. Comparative in-vitro drug release of INV-SLN and MCC coated INV-SLNs was done in 6.8 pH phosphate buffer for 12 hrs and 0.1N HCl for 2 hrs. Similarly in-vivo study was done by using Wistar rats. Relative oral bioavailability of MCC coated INV-SLNs was significantly increased as compared with INV-SLNs and INV-suspension. Stability-study was done as per ICH guidelines....
To overcome difficulty in swallowing tablets or capsules, scientists have considerably dedicated their effort to develop novel drug delivery systems which enhance safety and efficacy of drug molecule and to achieve healthier patient compliance. One such approach is mouth dissolving tablets (MDT). The purpose of this research was to mask the intensely unpleasant taste of tramadol HCl by inclusion complexation, complexing with resin and solid dispersion to formulate mouth dissolving tablets of the taste-masked drug. Tablets were formulated by wet granulation method using excipients. All formulations were evaluated for dispersion time, wetting time, % friability, content uniformity and in-vitro dissolution rate. Formulations with Kyron T314 showed the least disintegration time and wetting time. In-vitro drug release study of taste masked tablet showed complete drug release within 15 minutes and successful masking of taste and rapid disintegration of the formulated tablets in the oral cavity....
Febuxostat is an antigout drug. It exhibits poor bioavailability of about 49% which is attributed to its poor solubility. Gout is a metabolic disorder characterized by elevated uric acid levels in the body, associated with painful, tophi and nephropathy. Spherical agglomerates were prepared by simple agglomeration technique. Agglomerates were prepared by using dimethylformamide, methanol and water as good solvent, bridging liquid and poor solvent, respectively. The polymer polyvinyl pyrrolidone (PVP K-30) were used in spherical agglomeration process. The pure drug and agglomerates were characterized by fourier transfer infra red spectroscopy. FTIR study indicated that there was no chemical change in the agglomerates of febuxostat. Micromeritic and dissolution studies were carried out. Process variables such as amount of bridging liquid, stirring time and duration of stirring were optimized. The spherical agglomerates exhibited excellent dissolution rate as compared to febuxostat. The agglomerates also exhibited higher micrometric properties which indicate good compressibility and packability characteristics....
Now days, oral drug delivery of bilayer tablet are acquiring more acceptance among generic and brand product due to concourse of factors including advanced delivery strategies, combination therapy and patient compliance. This article provide an overview of bilayer matrix tablet technology, highlighting mainly hydrophilic matrix system of controlled release dosage form while providing a description of type of matrix system, their release mechanism and critical factor in the release of drug. Finally, a scheme for ELAN drug technology (DUREDAS™ Technology)’dual release drug delivery system of bilayer tablet manufacturing and selection of hydrophilic matrices is advised as a guideline to the formulation design and selection of process parameter....
Loading....